Title |
Molecular Basis of Viral and Cellular Transformation
|
Institution |
YALE UNIVERSITY, NEW HAVEN, CT
|
Principal Investigator |
DIMAIO, DANIEL
|
NCI Program Director |
Peter Ogunbiyi
|
Cancer Activity |
Comp Min Biomed Prog
|
Division |
CRCHD
|
Funded Amount |
$82,319
|
Project Dates |
05/01/1997 - 06/30/2009
|
Fiscal Year |
2007
|
Project Type |
Grant
|
Research Topics w/ Percent Relevance |
Cancer Types w/ Percent Relevance |
Aging (10.0%)
Gene Therapy (10.0%)
Hematology (20.0%)
Herpes - Genital (5.0%)
Herpes - Other (25.0%)
|
Cervical Cancer (65.0%)
Non Hodgkins lymphoma (25.0%)
|
Research Type |
Exogenous Factors in the Origin and Cause of Cancer
|
Abstract |
This is an amended application in which we propose four projects in years 31 to 35 of a successful Program to explore the molecular basis of viral and cellular transformation. In this revised application, we have deleted the two lower ranking projects and one core. The four remaining laboratories will carry out investigations into the role of viral gone products, interacting cellular proteins, and mutagenesis in cell transformation. Dr. Miller will continue his studies on the mechanism of viral transactivators that disrupt herpesvirus latency. Dr. DiMaio will continue his analysis of the role of the human papillomavirus E6 and E7 oncogenes in maintaining the proliferation of human cervical cancer cells, with a particular emphasis on determining the molecular basis for induced senescence that occurs upon oncogene repression. In a project centered on mutagenesis, Dr. Sweasy will continue her analysis of cancer-associated DNA polymerase B mutants and their ability to transform cells. Finally, Dr. Steitz will continue her studies establishing the biochemical activities of tumor virus-encoded small RNAs and determining their effects on host cell function. In addition, an administrative core and a scientific core will provide essential services to the Program. This Program represents the significant commitment of the Yale University School of Medicine and the participating investigators to studies that will have direct relevance to understanding the cause of human cancer. |